Spike, character on "Buffy the Vampire Slayer"
Spike, a baby dragon on "MyLittle Pony: Friendship Is Magic"
Spike Lavery, character on American soap "All My Children"
Spike Milligan, ex-burglar, friend to JimmyPitt, in P. G. Wodehouse's "A Gentleman of Leisure" (1910)
Spike Spiegel, main character from anime series "Cowboy Bebop"
SpikeFreeman, character on Australian TV series "Snobs"
Spike, Rhynoc boss from game "Spyro the Dragon"
Spike Scarlatti, character on TV series "Flashpoint"
Spike, Snoopy's older brother in "Peanuts"
Spike, a stegosaurus in "The Land Before Time" franchise
Spike and Suzy, British name for a Belgian comic
Spike, a word for a sharp point