The name Manuela is a girl's name of Spanish origin meaning "God is with us". Manuela and is often added to lists like Spanish Baby Names and discussed in our forums with posts like "Makeover name game: from one gender to the other".
From the experts:
Manuela is one feminine form that's more energetic than the male original, and is worth considering if you're seeking an easily assimilated Spanish name.
In the 1948 film The Pirate, set in the Caribbean village of Calvados, Judy Garland plays a spirited senorita named Manuela. Manuela Santos is a fictional character in Degrassi: The Next Generation and there is a Manuela in the James Bond film Moonraker.