The name Flossie is a girl's name of Latin origin meaning "flourishing, prosperous". Flossie and is often added to lists like Vintage Nicknames for Girls and discussed in our forums with posts like "Quintuplet Game-GIRLS".
From the experts:
Flossie was an extremely popular Florence nickname that was used independently in the early twentieth century, given to over five hundred girls per year a century ago. Flossie was one of the younger twins in the iconic children's book series The Bobbsey Twins, first published in 1904. Appealing, if a little cutesy--sweet as candy floss. A similar name is Florrie.