The name Gene is a girl's name meaning "wellborn, noble".

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Jean is primed to rise again – particularly in the middle slot. So could Gene follow suit? 
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This spelling is still more commonly a male name, short for Eugene or given as a standalone, but it works as a nickname for Eugenie, Genevieve, Imogene, Georgina and several other stylish female names.

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Gene

The name Gene is currently ranked #907 in U.S. births. and peaked for girls at #352 in 1925. It is currently rising in popularity. Gene is occasionally used for boys in 2025.

Eugenia

Jean

The name Gene is a boy's name meaning "wellborn, noble".

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Like Ray, a formerly funky nickname name that is newly cool. Comedian Amy Schumer used it for her son. 
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While technically Gene is short for Eugene, it can certainly be used on its own as an honor name for grandpa Eugene or even grandma Jean.

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The name Gene is currently ranked #923 in U.S. births. and peaked for boys at #61 in 1937. It is currently rising in popularity. The name is most popular in GENE, GENE, and GENE. Gene is occasionally used for girls in 2024.

Eugene

Year	US rank	Births	Per million
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2020	—	0	0
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2022	—	0	0
2023	—	0	0
2024	—	0	0
2025	—	0	0

Gene

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