Yoko Tsuno, title character in a Belgian comics series by Roger Leloup
Yoko Littner, character in anime series Gurren Lagann
Yoko Suzuki, character in game Resident Evil: Outbreak
Yoko, Japanese cat on animated series Timothy Goes to School
Yoko, character on TV series 'Raised by Wolves'
Yoko Nakajima, a character in The Twelve Kingdoms
Yoko Belnades, a supporting character in the Castlevania series
Yoko Herene, a character in 'My-Otome
Yoko Kuno, a character All About Lily Chou-Chou
YokoMachi, a character in Bokurano: Ours
Yoko Matsutani, a character in Legendz
Yoko Minato, a character in Kamen Rider Gaim
Yoko Okino, a minor character in anime Case Closed/Detective Conan Yoko Usami, a main character in Tokumei Sentai Go-Busters
Yoko, a character in Inukami!
Yoko, a character in the 2004 film The Grudge
Yoko, the birth name of the main character in the manga Gunnm