The name Ramona is a girl's name of Spanish origin meaning "wise protector". Ramona is ranked #893 on our popularity charts and is often added to lists like Unique Vintage Names for Girls and discussed in our forums with posts like "Girls Makeover - Two Middles".
From the experts:
Ramona is a Sweet Spot name--neither too trendy nor too eccentric. Kids will associate it with the clever Ramona Quimby character in the series of books by Beverly Cleary, also seen on TV. It was chosen by starcouple Maggie Gyllenhaal and Peter Sarsgaard for their little girl, who would be joined by sister Gloria.
Ramona came into prominence in the 1880's via the beautiful half Native American heroine of the best-selling eponymous romance novel by Helen Hunt Jackson, played on screen by Loretta Young. and others.
Trivia tidbit: Ramona is the middle name of singer Avril Lavigne.