The -ie version is usually for girls, with the simple e ending—pronounced the same as Jessie—for boys, though the spellings sometimes cross gender lines.

Jessie has never been used as much as Jennie/Jenny, partly because it's a boys’ name as well (spelled Jesse), but it does have a friendly and unpretentious pioneer feel. In Scotland, it's found as an Anglicized form of Teasagh, itself a form of Jean, and is used as a full name. And in the rest of the world, Jessie may be short for Jessica or used on its own.