Xavier originated is use as a given name after Saint Francis Xavier, cofounder of the Jesuit order, who got his name from the Spanish-Basque village where he was born. His birthplace was Javier, the name of which was derived from the Basque place name Etxeberria, meaning "castle" or "new house."

The gorgeous and romantic name Xiomara popped into the Top 1000 from 2004-2011 after a contestant on America's Next Top Model increased interest in her rare name.

Xanthia gets this classic Greek name closer to the modern Cynthia, sometimes used as its Anglo equivalent.