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Serafino Belfanti (1860–1939), Italian immunologist
Serafino Biagioni (1920–1983), Italian bicycle racer
Serafino Cretoni (1833–1909), Italian Cardinal of the Roman Catholic Church
Serafino De Tivoli (1826–1892), Italian artist of the Macchiaioli group
Serafino dell' Aquila (1466–1500), Italian poet and improvisatore
Serafino Ghizzoni (born 1954), former Italian international rugby union footballer
Serafino Mazzolini (1890–1945), Italian lawyer, politician and journalist
Serafino Mazzarochi (1890–1961), Italian gymnast who competed in the 1912 Summer Olympics
Serafino Porrecta (1536–1614), Italian-Dominican theologian
Serafino Vannutelli (1834–1915), Italian Cardinal
FrankCarltonSerafino Feranna, Jr., birth name of singer Nikki Sixx
