Xavier originated is use as a given name after Saint Francis Xavier, cofounder of the Jesuit order, who got his name from the Spanish-Basque village where he was born. His birthplace was Javier, the name of which was derived from the Basque place name Etxeberria, meaning "castle" or "new house."

Xander is a diminutive of Alexander, the Latin variation of the Greek Alexandros. Its meaning, "defending men," is taken from the Greek roots aléxein, "to defend," and andros, "men." Zander, pronounced the same way, is an alternate spelling.

The two X's may be a challenge for even the most intrepid baby namer. Xerxes was the name of two early kings of Persia and the Handel opera Serse or Xerxes is loosely based on Xerxes I.

Spelt Xanthos in Greek, this alternate name for Apollo has a noble sound (pronounced ZHAN-thus) and can always be shortened to Xan.