Xavier originated is use as a given name after Saint Francis Xavier, cofounder of the Jesuit order, who got his name from the Spanish-Basque village where he was born. His birthplace was Javier, the name of which was derived from the Basque place name Etxeberria, meaning "castle" or "new house."

Xander is a diminutive of Alexander, the Latin variation of the Greek Alexandros. Its meaning, "defending men," is taken from the Greek roots aléxein, "to defend," and andros, "men." Zander, pronounced the same way, is an alternate spelling.

The invented name Xael debuted on the charts for boys in 2010. It is primarily used among Spanish-speaking families.