Although Maguire is such a prominent Irish surname —it ranks in the Top 40 in the Emerald Isle —this lively and cheerful family name has rarely been used as a first, unlike more familiar examples like Ryan, Riley and Reagan. The powerful and distinguished Maguire clan was known for their courage, leadership and resilience. The name's many notable associations include the unionizing Pennsylvania coal miners known as the Molly Maguires, actor Tobey Maguire and Dixie Chick Martie Maguire. Other spellings are McGuire and McGwire; two other handsome Irish surnames to consider are Malone and Magee.

Easy nickname Maggie makes Maguire an appealing option for girls.