Spike, character on "Buffy the Vampire Slayer"
Spike, a baby dragon on "MyLittle Pony: Friendship Is Magic"
Spike, Kendall's baby on "All My Children"
Spike Milligan, ex-burglar, friend to JimmyPitt, in P. G. Wodehouse's "A Gentleman of Leisure" (1910)
Spike, a word for a sharp point
Spike Spiegel, main character from anime series "Cowboy Bebop"
SpikeFreeman, from the Australian TV series "Snobs"
Spike, Rhynoc boss from game "Spyro the Dragon"
Spike Scarlatti, character on TV series "Flashpoint"
Spike, Snoopy's older brother in "Peanuts"