Seymour Cray, American electrical engineer
Seymour Myron "Sy" Hersh, American investigative journalist
Seymour Cassel, American actor Philip Seymour Hoffman, American actor
Seymour Hicks, British actor
Seymour Martin Lipset, American sociologist
Seymour Krelborn, main character in "Little Shop of Horrors"
"Seymour Stein," song by Belle and Sebastian
Seymour Guado, character in video game "Final Fantasy X"
Seymour Birkhoff, character on TV's "Nikita"
Principal Seymour Skinner, character on TV's "The Simpsons"
Seymour Glass, character in J.D. Salinger's fiction