Roxanne Ritchie, character from the animated film Megamind (voiced by TinaFey)
Roxanne Bojarski, character on the show American Dreams
Roxanne, song by The Police Tango de Roxanne, a song from the movie Moulin Rouge
Roxanne, the Rustboro City Gym Leader in Pokemon Ruby/Sapphire/Emerald
Roxanne, the love interest of Max Goof in "A Goofy Movie"
Roxanne "Roxy" Ryan, character from "NewYork Minute"