Roxanne Ritchie, character from the animated film Megamind (voiced by TinaFey)
Roxanne Bojarski, character on the show American Dreams
Roxanne, song by The Police Tango de Roxanne, a song from the movie Moulin Rouge
Roxanne, the Rustboro City Gym Leader in Pokemon Ruby/Sapphire/Emerald
Roxanne, the love interest of Max Goof in "A Goofy Movie"
Roxanne "Roxy" Ryan, character from "NewYork Minute"
Roxanne Weasley, daughter of George Weasley and AngelinaJohnson in the epilogue of JK Rowling's "HarryPotter" series.