José Manuel "Pepe" Reina (Páez), Spanish footballer
Képler Laveran "Pepe" Lima Ferreira, Portuguese footballer MarcosPaulo "Pepe" Aguiar de Jesus, Brazilian footballer
José Manuel "Pepe" Soares, Portuguese footballer
José Alberto "Pepe" Mujica Cordano, 40th President of Uruguay JuanIgnacio "Pepe" Sánchez (Brown), Argentine basketball player
Pepe Rey, main character in "Doña Perfecta" (1876) by Benito Pérez Galdós; tolerant and loving young man destroyed by forces of reaction
Pepe the King Prawn, Muppets character
Pepe el Toro, main character in the Nosotros los Pobres film series
Pepé Le Pew, Looney Tunes skunk character
Pepe, character in the manga "Shugo Chara!"
Pepe, character in "Unseen Academicals" by Terry Pratchett
Pepe the Frog, aka "One Sick Meme"