Orson has had in the past a rotund teddy-bear image, a la Orson Welles, who early on dropped his common given name of George in favor of his more distinctive middle one, and who seemed to own it during his lifetime. No longer a single-person signature, it's now an interesting possibility for any parent seeking an unusual yet solid name. It's started to appear to the celeb set--both Paz Vega and Lauren Ambrose have little Orsons.
The comic actor Orson Bean was born Dallas; there is a "Desperate Housewives" character called Orson Hodge.
There's also a fifteenth century story about two brothers named Valentine and Orson, in which the latter was carried off by a bear and raised as one of its cubs.