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Gender: F Meaning of Madonna: "my lady" Origin of Madonna: Latin

There's only one. Okay, two.

Famous People Named Madonna

Madonna Louise Ciccone, American singer
Cleopatra "Cleo" Madonna Higgins, American R&B singer of group Cleopatra

Pop Culture References for the name Madonna

Lady Madonna, Beatles song
Madonna of the Rocks, Da Vinci painting
This is a title for the Blessed Virgin Mary, esp. in paintings (i.e. Madonna and Child, etc.)