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Gender: F Meaning of Madonna: "my lady" Origin of Madonna: Latin

Popularity: this week.

There's only one. Okay, two.

Famous People Named Madonna

This is a title for the Blessed Virgin Mary, esp. in paintings (i.e. Madonna and Child, etc.)
Madonna (Ciccone) - American singer

Pop Culture References for the Name Madonna

Lady Madonna, Beatles song
Madonna of the Rocks, Da Vinci painting

Madona