Locke Cole, treasure hunter in video game "Final FantasyVI"
Locke Lamora, main character in The Gentleman Bastard series by ScottLynch
Locke, pseudonym of Peter Wiggin in novels by OrsonScottCard
Locke the Echidna, character in the Sonic the Hedgehog comic books
Chōjin Locke, main character in manga "Locke the Superman"
Locke Vinetti, main character in Christopher Krovatin's "Venomous" John Locke, character on TV's "Lost"