Lissa, character in the second book of the Maximum Ride series
Vasilissa "Lissa" Dragomir, character in the Vampire Academy series
Lissa Mullan, character in "What's Left of Me" by Kat Zhang
LissaMiller, character in MTV's "Awkward"
Lissa, character from video game "Fire Emblem: Awakening"
Lissa, island in the Adriatic Sea (aka Vis)