Keiko Sofía Fujimori (Higuchi), Peruvian politician; former First Lady of Peru as daughter of President Alberto Fujimori
(Christine) Keiko Agena, American actress
Keiko Fuji (born Junko Utada), Japanese pop singer and actress
Keiko Han, Japanese voice actress and singer
Keiko Nakazawa, Japanese adult film actress
Keiko Toda, Japanese voice actress
Keiko Takemiya, Japanese manga artist
Keiko Matsuzaka, Japanese actress
Keiko Okabe, character in "Hotel on the Corner of Bitter & Sweet"
Keiko, character from American/Canadian show "The Troop"
Keiko Yukimura from YuYu Hakusho
Keiko O'Brien, a character in Star Trek: The Next Generation and Star Trek: Deep Space Nine
may also be pr. KAY-ko or KEE-ko