Chef Jeff Reycraft, character on TV's "Switched at Birth"
Jeff "The Beast" Sussman, character on TV's "The King of Queens"
Jeff Albertson AKA Comic Book Guy, character on 'The Simpsons'
Jeff Winger, character on TV series "Community"
"Jeff, Who Lives at Home", American film starring Jason Segel
Jeff "Joker" Moreau, the snarky pilot of the Normandy in the Mass Effect trilogy.
Jeff the Killer, a "Creepypasta" character