Gene Kelly, American actor, singer, and dancer
Gene Roddenberry, American TV screenwriter
Gene ElliottThornton, Jr. aka No Malice, American rapper
Gene Wilder, American actor
Gene Hackman, American actor
Gene Belcher, character in animated series "Bob's Burgers"
Gene Vidal, character in movie "Amelia"
Gene Friesen, character in TV series "Eastwick" Eugene "Gene" Draper, third child of DonDraper on TV's "Mad Men"
Gene, character in video game "Metal Gear Solid: Portable Ops"
Gene, main character in video game "God Hand"
Gene Forrester, main character in "A Separate Peace" by John Knowles