This is an offshoot of Duane, which is an old Irish surname. It took off in the 1960s, when it conveyed a surfer boy image, and reached as high as Number 111 in 1961. The most prominent current bearer is Dwayne "The Rock" Johnson.
Dwayne Cleophus Wayne - Lead character on "A Different World"
Dwayne Banbury, from TV series "Mysterious Ways"
Dwayne Hicks, from the movie "Aliens"
Dwayne, character in "The Wolf of WallStreet" (2013 film)
Dwayne Myers, police officer from BBC's Death in Paradise