This is an offshoot of Duane, which is an old Irish surname. It took off in the 1960's, when it took on a surfer boy image, and reached as high as Number 112 in 1961. Most prominent current bearer is Dwayne "The Rock" Johnson.
Dwayne Cleophus Wayne - Lead character on "A Different World"
Dwayne Banbury, from TV series "Mysterious Ways"
Dwayne Hicks, from the movie "Aliens"
Dwayne, character in "The Wolf of WallStreet" (2013 film)