(Giuseppe) Domenico Scarlatti - Baroque composer, most noted for his harpsichord sonatas
Domenico Ghirlandaio, an Italian Renaissance painter from Florence. Michelangelo was an apprentice under him.
Domenico Zampieri (or more well known as Domenichino, meaning, "Little Domenico"), an Italian Baroque painter
Domenico Modugno, known for his 1958 international hit song "NelBlu Dipinto DiBlu (Volare)".
Domenico Dolce, co-founder of Dolce & Gabbana with Stefano Gabbana.