Desmond is a sophisticated and debonair name, with noble ties to 1984 Nobel Peace Prize-winning Bishop Desmond Tutu, and with some great nicknames--Des/Dez, Desi/Dezi. It is beginning to catch on in the US, now at Number 330.
Another notable Desmond is British zoologist and anthropologist Desmond Morris, author of The Naked Ape and other popular books.
The character Desmond David Hume on Lost was named in tribute to philosopher David Hume, and the name also appears on Oz; Desmond Harrington plays Detective Joseph Quinn on Dexter.
And we can't forget all the references to Desmond in the Beatles song "Ob-La-Di, Ob-La-Da"--possibly used in tribute to reggae singer Desmond Dekker.