John Clayton Mayer, American guitarist, singer-songwriter, producer
Clayton Holmes "Clay" Aiken, American singer-songwriter and TV personality Ernest Clayton "Clay" Walker, country music artist
Clayton Moore, American actor best known as the "The LoneRanger"
Clayton Morris, American TV journalist
Clayton "Clay" Buchholz, American baseball pitcher
Clayton Kershaw, American baseball pitcher
Clayton Stoner, Canadian ice hockey player
Clayton Anderson, NASA astronaut
Clayton Watson, American actor
Clayton Andrew Donaldson, English footballer Adam Clayton, bassist of Irish rock band U2
Clayton Jones, character in the TV show "Carnivale"
Clayton Andrews, character in the DanielleSteele novel "Zoya"
Clayton Harding, character in movie "How to Lose Friends and Alienate People"
Clayton Danvers, a character from the "Women of the Otherworld" Series John Clayton aka Tarzan and his father, characters in the Tarzan series
Clayton, villain in Disney's "Tarzan" movie
Clayton Newman, character in comic strip "Adam@Home"
"Michael Clayton," 2007merican drama film starring GeorgeClooney