Annie is one of the most open and optimistic, the-sun'll-come-out-tomorrow type of name, having been celebrated over the years in song (Annie Laurie), comic strip (Little Orphan Annie), folklore (Annie Oakley, born Phoebe), and film (Annie Hall). It strikes a nice old-fashioned-but-jaunty chord that still has appeal, but we do suggest that you consider putting a more formal version on her birth certificate.
 Still well used, Annie was a Top 20 name from the 1880s to 1907.

Annie

Ahri

Akali

Alistar

Anivia

Ashe

Azir

Braum

Caitlyn is following all variations on the Irish classic Caitlin down the US baby name charts, following decades of popular usage. The original Anglicized form Kathleen is now starting to feel fresher than these more modern forms. 

 Transgender athlete and former Kardashian spouse Caitlyn Jenner chose this spelling for her post-transition name in 2015.

Caitlyn

Cassiopeia, the name of a mythological mother who became a stellar constellation, is challenging but intriguing, and has all those softening Cass nicknames available. And with all names Cass-related trending, Cassiopeia may be an unusual route to a stylish name.

With the rise of other otherworldly and mythical choices, from Apollo to Jupiter to Juno, Cassiopeia may just feel more possible for mortals now than ever before in its long history.

Some sources say the meaning relates to the cassia berry or tree, and may be "cassia juice," making this a botanical as well as a mythological name.

Cassiopeia

Darius is a historic name via Emperor Darius the Great, a key figure in ancient Persian history, and several other Persian kings. His name today has an appealingly artistic image, which might well be found on a concert program or gallery announcement. 
 Among its cultural inspirations is composer Darius Milhaud. Journalist Christiane Amanpour, who was raised in Tehran, named her son Darius.

Darius

Diana, the tragic British princess, inspired many fashions, but strangely, not one for her name. For us, Diana is a gorgeous and still-underused choice.
 Diana is the Latin name for the Roman goddess associated with the moon, virginity, and hunting; she is the protector of wild animals, represented in myth as both beautiful and chaste.
 Two of her most prominent bearers today are singers Diana (born Diane) Ross and Krall. Fictional Dianas appear in All's Well That Ends Well, Jane Eyre, and Anne of Green Gables.
 Now that the Duke and Duchess of Cambridge have named their daughter Charlotte Elizabeth Diana, perhaps this name will finally attract more attention and greater use.

Diana

Inspired by Brandon Lee's character in The Crow and Cuba Gooding Jr.'s in In the Shadows, this name, with its Wiccan feel, was used by a member of Linkin Park. It has ranked in the US Top 1000 since 1995.

Draven

Elise is one of those golden names that stylish but not TOO popular. Its appeal is due in large part to its French flair and to the love for El-names in general.
 
Elise originated as French diminutive of Elizabeth but is now most commonly used as self-contained name. In English and French speaking countries, Elise is pronounced with two syllables, but in countries with Germanic or Scandinavian languages it is pronounced with three syllables, closer to Elisa. 
 Elise was introduced into the English-speaking world in the late nineteenth century. Today, it can make an original, modern honor name for an ancestral Elizabeth.
Emily Blunt played a character named Elise in The Adjustment Bureau. Fur Elise is one of Beethoven's most popular piano pieces. Piers Morgan named his daughter Elise.

Elise

The extra N gives a trendy feel to the classic name Evelyn – part of a surge in names with -lynn suffixes.

With Evelyn now a Top 10 name, spelling variations are sure to rise too. Some parents may prefer the lynn ending because it clarifies pronunciation, distinguishing the name from Eveline, which rhymes with wine.

In fact, varying the ending of girls' names from -line to -lyn or -lynn has become standard practice in the US to differentiate Caroline from Carolyn, Adeline from Adelyn. Of course, many people pronounce both names as if they ended in -lynn anyway, but with the -lynn ending, there usually isn't any confusion.

Evelynn

Ezreal

Fiora is a lost name that's now been found, a sleeker version of the antique Fiorella. There's an Italian river called the Fiora as well as a character in the video game League of Legends: Fiora is known in that game as "The Grand Duelist".

Fiora

Galio

Garen

Gragas

Hecarim

Illaoi

Irelia

Jax is the Dex-Jex-Pax type of x-ending cool -- possibly too cool -- variation of Jack or nickname for Jaxon or Jackson.
 Jax was a soap opera character name way back when; most recently he's been seen as Jackson "Jax" Teller, the central character on Sons of Anarchy, the national president of the Sons of Anarchy Motorcycle Club.

Jayce, which probably started out as an abbreviation of names like Jason, with the 'y' borrowed from Jayden, now has a life of its own, making a strong showing on the popularity lists.

Jayce

Janna

Jarvan

Jhin

Kalista

Some parents, including rapper Ludacris, are literally bestowing good karma on their children; it could just join the new spiritual name congregation. 

Karma

The Russian version of Katherine is usually Ekaterina, but this Slovak form is used throughout Eastern Europe and may be more friendly to the American ear.

Katarina

Kayle is a quietly-used name for girls perhaps best known as the name of a female champion in League of Legends. There are many males named Kale but few with this spelling. And then of course there's the vegetable.

Kayle

Karthus

Kassadin

Kennen

A Top 100 name from 1896 to 1921, Leona reached as high as Number 72.
Since then, Leona had seemed to be one of the most unfashionable of the pride of lion names, but singer Leona Lewis has done a lot to rejuvenate it.

Leona returned to the Top 1000 in 2009 after decades of being away. 
 A somewhat more sophisticated option is the French Leontine.

Leona

Lucian is a sleeker, more sophisticated version of Lucius that is climbing in tandem with other Lu-starting names.
 Historically, the name was made famous by the ancient Greek satirist Lucian of Samosata--sometimes considered the father of science fiction-- and by the third century St. Lucian.
 A modern bearer was Berlin-born British painter Lucian Freud, grandson of Sigmund. In pop culture, Lucian the Lycan is a werewolf in the Underworld movies. 
 Lucian was picked by Indie actor Steve Buscemi. Lucien is the French version. The attractive Italian form is Luciano, as in Pavarotti.

Lucian

Lula has a firecracker personality, a singing and dancing extrovert. Interesting that Lulu was a Top 100 name when the Social Security list was born in 1880, but it's been sliding ever since and has not been in the Top 1000 for decades. Modern parents in love with Lulu might well reverse that trend.
 Lulu is the now grown daughter of musicians Edie Brickell and Paul Simon. In the Swinging London sixties, Lulu was a popular single-named Scottish singer--whose birth name was Marie.

Lulu

This name of a character played by Kirsten Dunst in the movie Virgin Suicides, originally a novel by Jeffrey Eugenides, is gaining attention, also thanks to the heroine Lux, Lady of Luminosity in the League of Legends games. Luz is the Spanish version.

Lissandra

Malcolm is a warm and welcoming Scottish appellation (originally Mael-Colium) that fits into that golden circle of names that are distinctive but not at all odd. A royal name in Scotland, Malcolm is also a hero name for many via radical civil rights activist Malcolm X. 
 Malcolm was the name of four Scottish kings — including the son of Duncan who succeeded to the throne after Macbeth murdered his father — and has been a standard in that country.
 Denzel Washington named one of his sons Malcolm, as did Harrison Ford.
 Actor Malcolm McDowell is one current bearer. Other namesakes are writer Lowry; bestselling author and trendspotter Gladwell; Sex Pistols musician McLaren; and actor Jamal Warner. There have also been several Malcolms on TV — e.g., in Malcolm in the Middle, Firefly and in the Outlander series. There were no fewer than three characters named Malcolm in the Harry Potter books.

Malcolm

Since Morgan is used as--or more--frequently for girls as for boys, this feminization has fallen by the wayside. It drew some brief attention via the pop singer Morgana King. 
The similar Morgiana appears in Tales from the Thousand and One Nights.

Morgana

Malzahar

Maokai

Nami

Nidalee

Olaf, though sainted and regal in Norway, is slightly oafish here. It is one of those names that has become completely familiar in the U.S. without ever becoming assimilated. Now that he's a comical character in Disney's Frozen, he might get some more attention.
 Olaf's solid Scandinavian history includes various kings of Norway, from the eleventh century St. Olaf (often mentioned by the Betty White character on Golden Girls) to the recent Olaf V.

Olaf

Orianna

Poppy, unlike most floral names which are sweet and feminine, has a lot of spunk. Long popular throughout the rest of the English-speaking world, Poppy is finally starting to rise toward the top in the US, where it entered the Top 1000 for the first time in 2016.

 British TV chef Jamie Oliver used the name for his eldest daughter, Poppy Honey Rosie, as did Anthony Edwards, Jessica Capshaw, and Anna Paquin and Stephen Moyer. A notable adult Poppy is Australian Without a Trace star Poppy Montgomery (full name Poppy Petal Emma Elizabeth – she and her sisters are all named after flowers: Lily, Daisy, Marigold and Rosie).

 Due to the flower's bold crimson color, Poppy makes an especially good choice for a redhead. In the UK, it is a traditional <a href="https://nameberry.com/list/605/names-for-november-babies">name for November babies</a>, due to the flower's association with Remembrance Day (Nov 11), honoring the memory of members of the Armed Forces who have died in the line of duty.

 Other Poppy-like names to consider: Pippa, Piper, Posey and Petal.

Poppy

Pantheon

Quinn is one of the first popular Irish unisex surnames, a strong and attractive choice on the rise for girls but still popular for boys. Quinn was used for about 3000 baby girls and 700 boys in the US last year.
 
Quinn is the Anglicized version of the Irish patronymic surname Ó Cuinn, meaning "descendent of Conn." Conn has two possible derivations—the Old Irish cond, meaning "intellect," or cenn, meaning "chief." One of the most notable Quinn clans was from County Tyrone in Northern Ireland. 
 Quinn started taking off for girls in the mid-nineties, possibly influenced by the popular show Dr. Quinn, Medicine Woman. Since then, there have been female Quinns on the animated MTV show Daria, on Zoey 101, and—most prominently—on Glee, featuring cute blond cheerleader character Quinn Fabray.
 Some other, more <a href="https://nameberry.com/lists/category/unusual-names">unusual names</a> with the Q-factor: Quincy, Quintina, Quintana, Quinta, Quilla--and, on a different note, Queenie.

Quinn

Riven

Sarah was derived from the Hebrew word sarah, meaning "princess." Sarah is an Old Testament name—she was the wife of Abraham and mother of Isaac. According to the Book of Genesis, Sarah was originally called Sarai, but had her name changed by God to the more auspicious Sarah when she was ninety years old.
 
Sarah is a timeless classic, as perpetually stylish as it is traditional. Sarah is still widely used, but with such a range of images and variations that any child can make it her own.
 
Sarah was a Top 10 name from 1978 to 2002, and though it has slipped in popularity, it's still one of the most widely used <a href="https://nameberry.com/search/baby-names-starting-with/s">names that start with S</a>. The Sara spelling is another popular option, and diminutives Sadie and Sally are used independently.
 
A few of her many prominent namesakes are iconic actress Sarah Bernhardt, jazz singer Sarah Vaughan, comedian Sarah Silverman, and actress/fashionista Sarah Jessica Parker.

Sarah

More modern options: Shaw, Shay, or even Sean. 

Shauna

This Welsh form of John is pronounced Shaun. But most Americans certainly wouldn't know that.
Siôn Corn (showing the extra-authentic spelling) is the Welsh name for Santa Claus.

Sion

Sejuani

Shen

Shyvana

Sivir

Sona

Soraka

Syndra

Taric

A more substantial but less-popular feminization of Tristan, the originally-male mythological name now used for girls as well as boys.

Tristana

Taliyah

Tryndamere

Udyr

The Viktor form of this classic name is widely used throughout Europe and is rising in the US as well.

Viktor

Vladimir is a cultured and deep-rooted Slavic name associated in this country with cultural figures including piano virtuoso Vladimir Horowitz and the author of Lolita, Vladimir Nabokov.

 The name Vladimir is rich in history, notably borne by Vladimir the Great, the 10th-11th century ruler of Kievan Rus' who brought Christianity to his nation and is now venerated as a saint in the Eastern Orthodox Church. Among the name's other famous – or infamous – bearers are several Russian political figures past and present, including Bolshevik leader Vladimir Lenin and current Russian president Putin. 

 Volodymyr is the Ukrainian form of the name, recently made internationally famous by Ukraine's president Volodymyr Zelenskyy following the Russian invasion of his country. Other variations of this name in other European countries include Valdemar and Waldemar. All derive from Slavic roots vladěti, meaning "to rule," plus meru "great" or miru, "peace" or "world." Common Slavic diminutive forms include Volodya, Vova, Vladan and Vlatko.

 Long a common name throughout the Slavic world, Vladimir is featured in novels by Turgenev and Pushkin. Vladimir also has vampirish connections: Dracula is based on Vlad III, three-time ruler of Wallachia in the 15th century, otherwise known as Vlad the Impaler. A more modern literary character is Vladimir, one of the two main figures in Samuel Beckett's play Waiting for Godot.

Vladimir

Varus

Warwick

Xerath

Alas, poor Yorick, your name is fated to remain locked forever as a skull in Hamlet.

Yorick

Yasuo

A popular nickname that, over the past few decades, has acquired enough standing to work on its own, a la earlier equivalents such as Jack and Max; an alternative to Zach/Zack. 
Actor/singer Zac Efron--born Zachary--is an attractive current bearer.

Newer than Zac, cooler than Ed, Ned, or Ted.

Zilean

Zyra

MercyxLolita's list "League of Legends Names" of 78 great name ideas: Annie - Zyra!

League of Legends Names

With over 100 characters to choose from, I was bound to find some pretty unique names in this game. 
(Note: Some are more usable than others-some of the more unique names I don't recommend for a real child, but maybe for a character in a story.)