Results 786 to 790 of 3227
Thread: Ttc 2013
April 23rd, 2013 05:01 PM #786
I am too lazy to write my own summary, so here goes ..."Researchers found the use of NSAIDs during pregnancy increased the risk of miscarriage by 80%. The timing and duration of NSAID use was also analyzed. A higher risk was found when the NSAID was taken around conception, which was defined as within the first week of gestational age or was used for longer than a week. The absolute risk of miscarriage associated with NSAID use during pregnancy ranged from 10% (any NSAID use) to 35% (use around conception), to 52% (use longer than one week)... The possible link between NSAID use and miscarriage in humans was first reported by Nielson et al (BMJ 2001;322:266-70). This study looked at the risk of adverse birth outcomes with the use of NSAIDs during pregnancy. It did not show a significant increase in the risk of congenital abnormality, low birth weight, or preterm birth with the use of an NSAID during pregnancy. However, there was a significant increase in the risk of miscarriage. Li et al provides more evidence of an association between NSAID and aspirin. The evidence does seem to support the findings from animal studies which indicate NSAIDs might block embryo implantation. It is believed that prostaglandins are needed for implantation of the embryo into the uterine wall. Since NSAIDs and aspirin are prostaglandin inhibitors, they could theoretically prevent successful embryo implantation, resulting in miscarriage." NSAIDs and Miscarriage. Prescriber's Letter 2003;19:191012.
It is obviously your own decision if you want to take NSAIDs while trying to conceive and during the first two trimesters. My high risk OB specifically told me to avoid them. This was slightly devastating to me as my rheumatoid arthritis gets quite painful, and I certainly can't take anything stronger than Tylenol during my 12 hr work shifts! Talk to you neurologist about better symptom management of your migraines. Sumatriptan is pregnancy category C in the US & category B3 in Australia. Further, if your headaches are worse during menses, sumatriptan has an elimination half-life of 102-186 minutes (at 6 half-lives 98% of the drug is gone from your body provided you are a young healthy adult with fully working kidneys/liver/etc). For most formulations of Excedrin, it will provide a subtherapeutic dose of Tylenol, a subtherapeutic dose of aspirin, and a bunch of caffeine which is the ingredient most likely to help a migraine. Obviously, talk to you PCP or OB before re/starting any of the above medications!!
Sorry if it came off as preachy! I was going to write an update and respond to some of the dear berry comments, but my phone has 4% battery left and I have to get my chores done. Cheers.
Last edited by poppy528; April 23rd, 2013 at 05:08 PM.“And remember, my sentimental friend, that a heart is not judged by how much you love, but by how much you are loved by others.” L. Frank Baum, The Wizard of Oz
April 23rd, 2013 05:27 PM #788
Should also have mentioned premature closure of the ductus in the third trimester (third trimester only).
NSAIDs in the most recent, comprehensive clinical review (a 6 year long study where pregnancies were observed specifically to answer this question, whether or not the risk of miscarriage is increased when taking them) did NOT demonstrate any effect. No link whatsoever. 43% of women took an NSAID at some point in their pregnancy, 13% had a miscarriage, and there was absolutely no higher percentage of NSAID-takers among the women who experienced miscarriage.
http://www.ncbi.nlm.nih.gov/pubmed/22914399 from July 2012
OBJECTIVE: To estimate the association between over-the-counter nonsteroidal anti-inflammatory drug (NSAID) exposure during the early first trimester and risk for spontaneous abortion (gestation before 20 weeks of gestation) in a prospective cohort.
METHODS: Women were enrolled in the Right from the Start study (2004-2010). Exposure data regarding over-the-counter NSAID use from the last menstrual period (LMP) through the sixth week of pregnancy were obtained from intake and first-trimester interviews. Pregnancy outcomes were self-reported and verified by medical records. Gestational age was determined from the LMP. Stage of development before loss was determined from study ultrasonography. Cox proportional hazards regression models were used to estimate the association between NSAID exposure and pregnancy outcome taking into account candidate confounders.
RESULTS: Among 2,780 pregnancies, 367 women (13%) experienced a spontaneous abortion. NSAID exposure was reported by 1,185 (43%) women. NSAID exposure was not associated with spontaneous abortion risk in unadjusted models (hazard ratio [HR] 1.01, 95% confidence interval [CI] 0.82-1.24) or models adjusted for maternal age (adjusted HR 1.00, 95% CI 0.81-1.23).
CONCLUSION: Our findings suggest that use of nonprescription over-the-counter NSAIDs in early pregnancy does not put women at increased risk of spontaneous abortion.
Here is the paper Poppy cited: http://www.ncbi.nlm.nih.gov/pubmed/11157526
It specifically studied women who were *prescribed* NSAIDs for pre-existing medical conditions in the several weeks preceding pregnancy and miscarriage. There is a major flaw with the study design: comparing sick women who need prescription medication and healthy women who do not is not comparing like with like. Obviously the major confounder is the preexisting medical condition, which is much more likely to lead to miscarriage. In addition prescription NSAIDs are stronger, more potent, and more regularly taken rather than the occasional advil for a backache. When the question was properly studied-- where the only variable was NSAID use in an otherwise medically uncomplicated patient population-- no effect was seen.XY: Antoine Raphael (3.1.2012)
XX: Cassia Viviane Noor (11.30.2013)
April 23rd, 2013 05:32 PM #790Senior Member
- Join Date
- Sep 2012
Doc!Married since June 2007, expecting our first child on Christmas Day, 2013
Darcy ~ Rowena ~ Hazel ~ Lorena ~ Leona ~
Eames ~ Miro ~ Bradbury ~ Duval ~ Marshall ~
April 23rd, 2013 05:41 PM #792
Congratulations on your pregnancy! We shall see. I feel pessimistic though... with Antoine I knew unmistakeably (of course I kept terrible, terrible track of my periods and was actually like 12 days late before I tested.... when I showed up to the OB I told her my LMP was in April, when in actuality it was May 15. She just rolled her eyes at me).XY: Antoine Raphael (3.1.2012)
XX: Cassia Viviane Noor (11.30.2013)
April 23rd, 2013 05:50 PM #794Senior Member
- Join Date
- Jul 2010
Thanks guys! You made me feel a lot better. 10DPO today -- yesterday I thought I saw something on one of my tests so I took a few more in two different types. I still don't see it on the skinny ones but on the thick ones I sort of do. Top ---> bottom is newest ---> old. Top is this morning, the rest are various times yesterday.
Inverted, because I see it better this way. I hope it gets darker!
http://i54.photobucket.com/albums/g1...ps46b96c21.pngAllie & Daniel -- Married since 08/2012 and TTC #1 since 04/2013
Aria - Azalea - Molly - Zoe - Katherine - Claire - Marie
Daniel Lucas - Isaac - Evan - Simon - Declan - Silas