I think it's unusual and cool, not heard of before, but not as recognizable so far as the "unfortuate meaning" thing goes. Desmona's cool, but it doesn't hhave quite the same meaning, and people might not connect the two in their minds. I'd still use it if you really like it, just a thought that you might want to take into considersation.
Cassandra--she always told the truth and even saw the future, but no one listened
Oh, yeah, I like Cassandra a lot!