Serafina Steer, English musician Saint Serafina aka Fina, 13th-century Italian child saint Lorenza "Serafina" Feliciani, wife of Italian charlatan Cagliostro
Serafina of God (born Prudentia Pisa), Venerable Italian Carmelite nun
Serafina Astafieva, Russian ballerina
Serafina Tortelli, Carla Tortelli's daughter on TV's "Cheers"
Serafina Pekkala, character in "His Dark Materials" trilogy
Serafina, character in X-Men comics
Oh, Serafina! (1976), an Italian comedy-drama film